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Metformin was studied in paclitaxel-treated mice, and the results indicate the effectiveness of metformin in attenuating hyperalgesia priming induced by paclitaxel through its stimulation of adenosine monophosphate-activated protein kinase (AMPK) [31]

(1998) study, presented in Table 3-12 (see Appendix D for more detailed analysis of the this study), makes it clear that the severity of symptoms and the severity and duration of exposures were all substantial and consistent for the cases, and the controls as a group had fewer symptoms and lower exposures

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