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USA 117 , 3061930627 (2020)

Modig K Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION

Peripheral Neuropathy Numbness Tingling Weakness Burning pain in the hands or feet Cognitive and Neurological Changes Memory difficulties Depression Irritability Fatigue Difficulty concentrating Sleep disturbances If left untreated for prolonged periods, some neurological complications may become irreversible

There are four different methods namely dose by factor, similar drug, pharmacokinetically guided, and comparative approaches are described in literature to assess the initial dose.[1] The dose by factor method is an empirical approach and use the no observed adverse effect levels (NOAEL) of drug from preclinical toxicological studies to estimate human equivalent dose (HED).[2] Here, the dose selection is based on minimum risk of toxicity, instead of choosing one with minimum pharmacologic activity in humans

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