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Thus, decreasing intracellular GSH renders tumor cells more susceptible to oxidative stress and chemotherapeutic drugs (9)

Genome Biol 4:R20

10.1016/j.lfs.2004.08.010 71 TudorM.JandricI.MarovicA.GjurasinM.PerovicD.RadicB.et al (2010)

Cell Biol Toxicol 42 , 39 (2026)

PMID 25957927

NADPH participates in biosynthetic reductions while NADH, which is not generated by the pentose phosphate shunt, is used primarily to donate electrons for oxidative phosphorylation to generate ATP