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Buyel, J

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The formation of amide bond can be addressed using EDC only, however, the resulting O-acylisourea intermediate exhibits less stability in aqueous conditions: this reduces its reactivity toward amine moieties (due to hydrolysis) and the reaction yield

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doi: 10.1016/0303-7207(95)03749-7

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5 mL aliquots were prepared, and 1000 worms were added in a volume of 1020 L

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Given the banal nature of supplementation, in addition to the low cost, our clinicians advocate supplements in some cases of melasma, pigmentary disorders & skin lightening

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