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Patients undergoing tear fluid analysis and interpretation of the cf-mtDNA can be roughly sub-grouped as follows: 1st group within the reference range

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Mitochondrial function and Cu storage are closely linked [5, 17], and the Cu-binding protein, COX17, plays a critical role in the transfer of Cu + from the cytoplasm to the mitochondrial intermembrane space

At present, clinical treatment options for DKD mainly include angiotensin converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (ARBs) and sodium-dependent glucose transporter 2 (SGLT2) inhibitors[3, 4]

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Wu X, Han Z, Schur RM, Lu ZR (2016) Targeted mesoporous silica nanoparticles delivering arsenic trioxide with environment sensitive drug release for effective treatment of triple negative breast cancer