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acute intermittent porphyria gutsandgrowth Frontiers Systematically Analyzing the Pathogenic Variations for Acute Intermittent Porphyria Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non human primates Gut Acute Intermittent Porphyria (AIP) is a rare metabolic disorder caused by a deficiency of the enzyme porphobilinogen deaminase., It presents with the classic triad:, Severe abdominal pain, Acute Intermittent Porphyria ; porphobilinogen deaminase Or hydroxymethylbilane synthase Deficiency Factors known to trigger or exacerbate acute attacks of porphyria [11]. Download Table

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