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Over the decades, the EAE model, focused primarily on T cells, has been the model for MS pathogenesis and treatment studies (Preiningerova et al., 2022)

ACSL3 can convert MUFAs to MUFA-pl, replacing PUFAs in the plasma membrane and alleviating ROS accumulation [79]

Furthermore, the rotational speed shows non-uniformity, and the maximum rotational speed was reduced to 57 r/min ( It was reported by another study that Polygonatum sibiricum polysaccharide (PSP), when intragastrically administered for six consecutive weeks to 6-OHDA induced PD model rats, increased the expression of PPAR- in the brain tissue of PD model rats at the eighth week ( Comparative analysis reveals both APS and PSP target neuroinflammation through distinct mechanisms: (1) APS directly suppresses cytokine production (IL-6/TNF-/IL-2), whereas (2) PSP activates PPAR--mediated transcriptional regulation