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Anaphylactic reactions are extremely rare but have been reported with GLP-1 receptor agonists

In a clinical trial of semaglutide injection for weight loss (Wegovy) in patients with T2DM and a BMI of 27 kg/m2 or more, hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

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Its anti-inflammatory effect includes decreasing levels of inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), making it a potential anti-inflammatory agent

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