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235 H 2 O 2 also increases threonine phosphorylation in Caco-2 cells by downregulating PP2A via oxidation of its redox-sensitive Cys266 and Cys269, forming inhibitory disulfide bonds, 236 particularly through oxidation of the B55 isoform

Studying mitophagy has been challenging in -cells, and its relevance was brought into question when loss of function studies on Parkin, a key regulator of mitophagy through ubiquitin-dependent autophagosome degradation, in -cells revealed no overt phenotype (Corsa et al., 2019)

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JCI Insight 2 (7), e90777