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If the 24-week trial could not demonstrate significant weight loss, there is no reason to believe that longer use would produce dramatically different results

8 Overall survival improvements were also noted in the CASTOR and POLLUX studies with the addition of daratumamab

Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)

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Contrave follows a different escalation pattern, building tolerance over four weeks to reach the target dose