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PMID: 14584018 National Institute of Mental Health [Internet] Bethesda, MD

Drug Test Anal, 5 (11-12), 850-852

The "kill" mechanism of Adipotide suggests a more permanent alteration to the animal's physiology, as the body does not rapidly regenerate destroyed adipose vasculature

Exogenous administration of FGF21 in DIO in mice show virtually no beneficial effects on glucose tolerance and lipid metabolism, suggesting that the obesity state is FGF21-resistant (240)