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The vast majority of studies across a range of countries have found an association between metformin use and vitamin B12 deficiency 71,144146 and potentially neuropathy, 147 though there are some exceptions

Due to these research interests, it remains a significant compound in studies related to injury recovery and regenerative biology

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Its concentration decreases significantly with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60

Dosage and administration Typical protocols in the literature and clinical practice use subcutaneous injection near the injury site, though oral and intramuscular routes are also used

Methods Patients who underwent PEID for lumbar disc herniation (LDH) were enrolled and randomly assigned to the single surgery (SS) group, where disc removal was performed via PEID alone, or the combined treatment (CT) group, which received epidural injections of dexamethasone and VB12 alongside surgery