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Transl Psychiatry 11:36

The naturally occurring LA form is the R-enantiomer which is also an essential cofactor involved in certain mitochondrial enzyme complex functions, whereas synthetic LA is a racemic mixture of both R- and S-forms in which the R-enantiomer is found more biologically active than the S-enantiomer

The entire EtfD structure also overlays well with an AlphaFold model (Jumper et al, 2021) of the membrane-bound two subunit heterodisulfide reductase HdrDE, which is found in archaea such as Methanosarcina barkeri (Fig

PMID: 37462205

The Activation of the Microglial NLRP3 Inflammasome Is Involved in Tuberous Sclerosis Complex-Related Neuroinflammation

Included studies had been undertaken in Africa and the Eurasia region, including all of Europe and the southwestern parts of Asia