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Recent studies have shown that upregulation of FAO occurs predominantly in conditions of nutrient deprivation, with dual inhibition of FAO (using etomoxir) and glucose metabolism (using 2-deoxy-D-glucose [2-DG]) yielding significant benefits in animal models of glioma [123]

10.1016/j.jhep.2016.07.009 93 RayS.MehtaN

Therefore, iron metabolism-targeted interventions not only modulate systemic iron homeostasis but also directly maintain mitochondrial integrity, providing a mechanistic basis for their therapeutic potential in IDD

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Dimers of mitochondrial ATP synthase form the permeability transition pore

Mazzatenta A, Pokorski M, Sartucci F, et al