doi: 10.1210/er.2017-00211
In vitro studies using PFFs to induce synucleinopathy in primary neurons showed that treatment with NAC reduced aSyn aggregates and oxidative stress 154
The research utilized male Sprague-Dawley rats and various in vitro and ex vivo experimental models [1]
Mundada K, Goel A, Paliwal VK, et al
Why IVF increases APD risk IVF protocols commonly require progesterone injections, suppositories, or oral formulations at doses much higher than those produced during a natural cycle Exogenous progesterone bypasses the bodys normal regulatory mechanisms, increasing the likelihood of mast cell activation and histamine release Repeated exposure during fertility treatment may unmask previously undiagnosed APD or worsen existing symptoms When progesterone desensitization is used Desensitization protocols may be recommended before or during IVF for individuals with known or suspected APD These protocols involve carefully supervised, incremental exposure to progesterone to reduce immune reactivity Desensitization is most often used when progesterone cannot be avoided, such as during luteal support or early pregnancy Role of antihistamines and corticosteroids during IVF Antihistamines (such as H1 and H2 blockers) are commonly used to blunt histamine-mediated symptoms during progesterone exposure Short-term corticosteroids may be prescribed to control severe inflammatory or allergic reactions during treatment cycles These medications do not treat the underlying hypersensitivity but can help protect patient safety and treatment continuity In some cases, clinicians may also consider antioxidant support such as NAC to help manage inflammatory stress during fertility treatment or pregnancy , though this should always be individualized
reported that uptake and cytotoxicity of oxaliplatin increased in HEK293 cells overexpressing rat OCTN1, rat OCTN2, human OCTN1, and human OCTN2, and that OCTN1-mediated transport of oxaliplatin seemed to make a greater contribution to its neuronal accumulation and neurotoxicity compared to OCTN2 or OCTs (Jong et al., 2011)
