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Secondly, in terms of cytokine network regulation, TMAO can promote the secretion of pro-inflammatory factors such as IL-6 and IL-12p40 by DCs, while inhibiting the production of anti-inflammatory factor IL-10

The viral hijack of human ACE2 receptor disrupts RAAS activation, upregulates NF-B pathway and the ensuing cytokine storm, hypertension, cell proliferation, inflammation, and fibrosis elicits detrimental effects on every bodily organ, the CV system, in particular 635

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However, long-chain fatty acids cannot simply diffuse across the impermeable inner mitochondrial membrane on their own

The reduction of TMAO in active IBD patients may reflect the depletion of TMA producing taxa caused by ecological imbalance, rather than ruling out the pathogenic role of TMAO