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Functional instability involves neuromuscular deficits including impaired proprioception, delayed muscle reaction times, and poor motor control that persist even when mechanical structures appear intact

GLP-1RA might also be valuable in knee osteoarthritis (KOA) amelioration, which represents the typical load-bearing complication of obesity and a leading cause of disability and reduced health-related quality of life

Kazuhiro Sakai, 2014 Generated progenitor cells for GABAergic and orexinergic neurons, offering targeted tools for sleep-wake circuit engineering

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In the major obesity and diabetes trials, Tirzepatide was typically studied at 5 mg, 10 mg and 15 mg maintenance doses , with escalation from a lower starting dose over a period of weeks to improve tolerability