Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44
All four LAB strains in this study showed antibiotic resistance to oxacillin, ciprofloxacin, and vancomycin
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Newer types of treatment target gastrointestinal -opioid receptors to minimize opioid induced constipation without diminishing analgesic effects, thus addressing a typical drawback to opioid therapy (58)
Data availability Data sharing not applicable to this article as no datasets were generated or analyzed during the current study
