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It was found that the levels of serum VB9 and VB12 in ASD group were lower than those in HC group, and the serum levels of the two B vitamins are correlated with the abundance of some intestinal flora ( However, no significant differences in plasma VB9 and VB12 between ASD and HC groups have also been reported ( The two vitamins, VB9 and VB12 play a role in amino acid metabolism, such as cysteine, methionine, and homocysteine conversion