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The antioxidant system involved in the defense against ferroptosis is mainly controlled by the transcription factor nuclear factor erythroid-2-related factor (NRF2), which is known to induce the expression of antioxidant enzymes and lipid detoxification enzymes [46]

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

This genotype also had higher catalase (CAT), superoxide dismutase (SOD), remarkable and dramatic increment in ascorbate-glutathione content, ascorbate-glutathione redox and ascorbate-glutathione cycle enzymes activity compared to sensitive genotype VA15

Results: QTc intervals and changes are presented in the table

Using monomeric derivatives of paeoniflorin (MDP) or removing ROS can reduce the phosphorylation of GRK 2 and inhibit FLS pyroptosis (155)

Related evaluation of their clinical application is still rare [267]