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Lysosomal accumulation of gliadin p31e43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARg downregulation in intestinal epithelial cells and coeliac mucosa

H., and Dawes I

In proximal renal tubular epithelial cells (TECs), autophagy inhibition, such as chloroquine or ATG7 depletion, reduces fibrosis, suggesting that autophagy may promote injury (Nam et al., 2019)

This finely regulated crosstalk ensures a balance between the supply and demand of carnitine in different physiological and pathological states, thus supporting the health and function of the whole organism

As a double edge sword, iron chelation may prevent labile iron catalysing ferroptosis, but may also disrupt energy production

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