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doi:10.1016/S2213-8587(17)30085-2 Rodbard HW, Lingvay I, Reed J, et al

One of the most noticeable of these is thinning skin, often leading to loss of firmness, heightened appearance of wrinkles, and a crepey texture

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High blood pressure (hypertension) is usually regulated by angiotensin-converting enzyme (ACE) via the kinin-kallikrein system (KKS) and the renin-angiotensin-aldosterone system (RAAS)