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Additionally, DA quinones can be oxidized to aminochrome, whose redox-cycling leads to the generation of the superoxide radical and the depletion of cellular nicotinamide adenine dinucleotide phosphate-oxidase (NADPH), which ultimately forms the neuromelanin (Sulzer et al., 2000) known to be accumulated in the SNpc of the human brain (Ohtsuka et al., 2013, 2014

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Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice

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It is an important pathogenic mechanism in metabolic diseases or fatty liver, and may become a key direction for improving MASLD