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With the advent of many combination analgesic medications, the potential for unintentional overdose has increased.3 In the United States, two concentrations of liquid formulations of acetaminophen for infants are now available, further increasing the risk of incorrect dosing.4 Acetaminophen hepatotoxicity is caused by the formation of a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI)

Importantly, the researchers found that supplementing the diet in the preclinical models with vitamin B12 and folic acid increased the levels of syntaxin 17 in the liver and restored its role in autophagy

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