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Moreover, we highlight recent therapeutic advances including the Food and Drug Administration (FDA) approval of resmetirom in 2024 and other promising agents currently in phase 2/3 trials providing a timely and translationally relevant overview that bridges current scientific evidence with emerging clinical applications in MASLD

However, the dominant mechanism linking AS and CVD appears to be the vulnerability of plaque (55)

10.1073/pnas.1115402109 137 GuerreroE

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death