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Chronic impairment of these systems, particularly during aging, renders dopaminergic neurons vulnerable to stress [210,224]

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The non-enzymatic succinylation is mainly mediated by intracellular succinyl-CoA which can be modulated by succinyl-CoA metabolism-targeting enzymes, such as OXCT1, a member of the CoA transferase family I [49], and SUCLA2/SUCLG2, the ADP-forming succinyl-CoA synthetase [32, 50]

219,220 The anti-inflammatory and immunomodulatory functions are mainly 14-ring and 15-ring

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The CPZ-specific overlap included 106 genes and was dominated by stress-response transcription factors ( KLF15, KLF9, KLF10, MAFK, CEBPG, JUNB and FOS )