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doi: 10.1007/s12035-016-0170-2 430 De BellisABellastellaGPerniceVCirilloPLongoMMaioAet al

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A randomized, double-blind, positive-controlled, prospective, dose-response clinical study to evaluate the efficacy and tolerability of an aqueous extract of Terminalia bellerica in lowering uric acid and creatinine levels in chronic kidney disease subjects with hyperuricemia

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It has been noted that these abnormal immune responses may be more pronounced within the first three years of the disease