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To bridge the preclinicalclinical gap, three concrete translational pathways are proposed: (1) Biomarker validation: Conduct prospective human cohort studies to verify preclinical biomarkers (e.g., GSDMD-NT for pyroptosis, HMGB1 for inflammation, MDA for lipid peroxidation, ferritin for ferroptosis) in serum and liver biopsies of EHS/CHS patients, establishing their diagnostic (early liver injury detection) and prognostic (MODS progression prediction) utility [59, 89]

Symptoms of a significant allergic reaction might include: Hives Extensive rash Swelling of the face, mouth, or throat Should an individual exhibit signs of anaphylaxis , a serious and potentially life-threatening condition, immediate medical attention is necessary

In contrast, left-sided colon and rectal tumors exhibit elevated mitochondrial activity and a greater reliance on OXPHOS [105]

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and setting 5, top 11 variables identified from a stepwise variable selection method)