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CDK5, cyclin-dependent kinase 5

The TGF- pathway is often dysregulated during aging, resulting in reduced collagen production, increased activity of extracellular matrix-degrading enzymes, and impaired cell regeneration

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TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA

Matsumoto, K., Funakoshi, H., Takahashi, H

In Marfan syndrome, a reduction of the skins elasticity happens, and Cushings syndrome may make the body produce a certain hormone at a higher level that causes rapid weight gain