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Proc Natl Acad Sci U S A 94(24):1308713092

Using the same site repeatedly causes lipohypertrophy (localized fat tissue thickening) that impairs absorption

To elucidate the systemic response to the MetR diet, we also performed RNAseq analysis of the abdomen upon four-week MetR, which contains the fat body, the major metabolic organ in Drosophila

It also can be a little irritating to sensitive skin at times, so you may want to test it out on a small patch of skin before using it all over your body