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The NQO1 bioactivatable drug, -lapachone, alters the redox state of NQO1 pancreatic cancer cells, causing perturbation in central carbon metabolism

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Analysis of CBC did not differ significantly among the groups with exception of white blood cells (WBC) that was at its highest level in patients with both T2DM and hypertension and the lipid profile parameters of this group, except for triglycerides, seemed significantly at a lower level when compared with patients with either T2DM or hypertension

In 12 newly diagnosed LN patients, synbiotic administration induced significant alterations in gut microbiota composition: the relative abundance of pathogenic bacteria (including Prevotella, Bacteroides , and unclassified Enterobacteriaceae ) decreased, whereas beneficial bacterial populations (such as Actinobacteria and Firmicutes ) showed marked increases [95]

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These results indicate that TLYYH effectively counteracts DSS-induced dysbiosis by restoring the balance between dominant bacterial phyla and promoting microbial homeostasis