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Fibrillation of -synuclein leads to the formation of a cross beta pleated sheet which causes cellular toxicity by creating pores in the membrane, inducing misfolding of other proteins and eliciting other signalling pathways which results in loss of cellular homeostasis

doi: 10.1089/jmf.2018.4259 48 SiddiquiJASharanKSwarnkarGRawatPKumarMManickavasagamLet al

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2.2 Intestinal microflora In contrast to the skin microbiota, the gut microflora may influence skin aging through intricate mechanisms involving immunological, neuroendocrine, and metabolic pathways

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