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Mechanistically, the bacterium activates microglia via the Toll-like receptor 4 (TLR4) signaling pathway, promoting the release of inflammatory factors (e.g., TNF-) and the formation of secretory vesicles that damage cerebral microvascular endothelial cells and ultimately disrupt the BBB [143,144,145,146]

10.1016/j.jep.2021.113933 38 BolouriP.SalamiR.KouhiS.KordiM.AsgariL

Mreaux, J.-L

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Ferroptosis is a type of regulated cell death characterized by the accumulation of intracellular iron and lipid ROS