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In the future, the integration of metabolomic readouts, single-cell and spatial transcriptomic localization, and metabolic modeling analysis is expected to establish a research framework of metabolic stratification-target selection-efficacy prediction, thereby reducing the risk of failed extrapolation across different diseases or populations (138)

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doi: 10.3389/fphar.2025.1592458 Received 12 March 2025 Accepted 07 July 2025 Published 31 July 2025 Volume 16 - 2025 Edited by Marcello Iriti, University of Milan, Italy Reviewed by Quansheng Feng, Chengdu University of Traditional Chinese Medicine, China omali Y El-khawaga, Mansoura University, Egypt Updates Copyright 2025 Wang, Yan, Zhang, Wang, Jiao, Zhu, Tan and Yang

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