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Human evidence note: While practitioner reports and early clinical experience are accumulating, large, controlled human trials are still limited

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Acetaminophen-induced oxidative stress results in lipid peroxidation, oxidation of protein thiols, mitochondrial injury, altered calcium homeostasis and DNA damage 43

Chemotherapy Drugs Platinum-based cancer medications, such as cisplatin, oxaliplatin, and carboplatin, are ototoxic medications and can cause tinnitus and hearing loss