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MSCs exert their therapeutic effects on PNI possibly through their dual functions, multipotent differentiation capacity into neural type of cells and their paracrine secretion of an array of bioactive factors with multiple trophic effects on both neural and nonneural cells [13], whereby the potent immunomodulatory effects of MSCs on immune cells, particularly macrophages, may constitute one of the major mechanisms by which MSCs exert their therapeutic effects on PNI [14]

[DOI] [PubMed] [Google Scholar] 212.Vaubourdolle M, Guechot J, Chazouilleres O, Poupon RE, Giboudeau J

Furthermore, during cellular uptake and metabolic absorption, EVs themselves degrade quickly or are actively cleared by the body, leading to a high degradation rate (Tran et al., 2020)