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Various studies targeting ER stress signaling pathways and components of the UPR have demonstrated that CHAC1 expression is upregulated downstream of the ATF4-dependent signaling pathway (Figure 4)

Keywords: diabetic peripheral neuropathy, diagnostic markers, pathogenesis, diabetes mellitus Introduction More than 50% of people with diabetes will develop diabetic neuropathy, which is one of the most common and troublesome complications of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM)

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Ustun S, Tombuloglu A, Kilinc M et al (2013) Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers

5 Therapeutic implications of sulforaphane The therapeutic potential of sulforaphane has gained increasing attention due to its ability to modulate oxidative stress and neuroinflammation