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In the best-case scenario for the SARS-CoV-2 virus, infection leads to a cascade of intracellular adaptations in which multiple networks are remodeled, from transcription to metabolism to signal transduction, shifting the invaded host cell from its original physiology into a SARS-CoV-2 replication system, and causing the emission of new viral particles and signaling molecules

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The dithiol mechanism, besides the catalytic cysteine residue, requires another cysteine residue (so-called recycling cysteine) that can be either the second cysteine residue of the Grx active site (Cys B ) or a cysteine residue apart from the active site (Cys C )

Binding at a threefold excess molar concentration of zinc revealed the second binding site of the metal at His50 in the N terminus but no additional affinity was noted for the C terminus

Figure 2 2.2