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doi: 10.1016/B978-0-12-416673-8.00013-7 166 HossainFSorrentinoCUcarDAPengYMatossianMWyczechowskaDet al

However, given the lack of proven benefits and documented risks, medical professionals advise all populations to avoid the practice

Meanwhile, elevated ROS activates pro-metastatic signaling pathways such as NF-B [263], promoting angiogenesis, extracellular matrix remodeling, inflammatory responses [318, 319], and epithelialmesenchymal transition (EMT) through upregulation of Snail and Twist [320]

Eligible studies specifically investigated the application of ctDCS for pain modulation, either in individuals with clinical pain or in healthy participants undergoing experimental pain induction