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This pathological alteration is not confined to the prostate gland itself but diffuses throughout the reproductive tract via high concentrations of inflammatory mediators in secretions (particularly TNF-, IL-1, IL-6, and IL-8), forming a widespread inflammatory microenvironment. Although the prostate is typically regarded as the primary inflammatory focus in CP/CPPS, relevant inflammatory mediators and the secondary immune responses they induce are believed to involve the testis and epididymis to a certain extent

Van Haasteren, J., Li, J., Scheideler, O

Synthesis and transport of GAP-43 in entorhinal cortex neurons and perforant pathway during lesion-induced sprouting and reactive synaptogenesis

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Stuttgart: Schattauer, 2004:54663