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Y.WangX.et al

Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

Taken together, these findings indicate a potential relationship between protein oxidation, Ca 2+ regulation, and protein aggregation in ALS (Fig

6.2.5 Implication for MFH These genetic axes motivate hypotheses that MFH actives could: (i) support mitophagy/mitochondrial quality control, (ii) reinforce endogenous redox buffering (e.g., Nrf2-GPX4), and (iii) dampen inflammation linked to mitochondrial stress