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16 Chronic Non-Healing Ulcers Impaired angiogenesis, together with dysfunctional matrix remodelling and chronic inflammation, contributes to the development of chronic non-healing ulcers

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This increase ion concentration interacts with the endoplasmic reticulum, which in turn activates calpain, enhances ROS production and ultimately disrupts cell function

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Toorop AA, et al