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One promising approach is targeting a protein called glutathione peroxidase 4 (GPX4), which is essential for preventing lipid peroxidation and protecting cells from ferroptosis

Comparison of quality of life, depression, anxiety, suicide, social anxiety and obsessive-compulsive symptoms between adolescents with acne receiving isotretinoin and antibiotics: a prospective, non-randomised, open-label study

Cheng JZ, Yang Y, Singh SP, Singhal SS, Awasthi S, Pan SS, Singh SV, Awasthi YC

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Notably, the PAG region receives no direct afferents from the striatum 44

Effect of dietary stilbenes on 5-lipoxygenase and cyclooxygenase activities in vitro