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The study addressed two questions: whether the fragment retained activity when delivered enterally rather than parenterally, and whether the effects observed in rodent models translated to human adipose tissue at the cellular level

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Instead, it is a preclinical synthetic small molecule that activates estrogen-related receptors and has produced exercise-associated metabolic effects in cells and animal models

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SAMe has also been found to be helpful in pain relief, depression, liver disease, and other conditions