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This apoptotic pathway is important for the down-regulation of the immune response, and its disturbance leads to buildup of proliferating lymphocytes resulting in lymphoid hyperplasia and autoimmunity (Rieux-Laucat et al., 2003)

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Treatment doses for deficiency are substantially higher, typically involving intramuscular injections of 1,000 g or oral supplementation of 502,000 g daily, depending on the underlying cause and severity

Direct measurement of the binding proteins is more informative when available." How should suspected biotin or heterophile-antibody interference change interpretation of an immunoassay-based B12 result