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Metabolic adaptation of the cellular component of the BM niche induces a HIF1-dependent glycolytic program, which increases CD73 and ADOR expression ( + ) (Figure 1, after consuming glucose at a higher rate than normal cells, MM cells secreted most of the derived byproducts as lactic acid, a phenomenon known as the Warburg Effect ( + ) results in acid accumulation within MM cells

GHK-Cu (copper tripeptide-1) is a naturally occurring tripeptide glycyl-L-histidyl-L-lysine that binds copper ions (Cu) with high affinity