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Validating Interactome Data from Yeast Two-Hybrid or Affinity Purification-Mass Spectrometry Studies High-throughput techniques like yeast two-hybrid (Y2H) screening and affinity purification-mass spectrometry (AP-MS) generate extensive lists of candidate protein interactions

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doi:10.1016/j.ajhg.2014.03.018

There have been negative effects observed as well, suggesting that DPI (and other related structures) act as pro-oxidants by decreasing GSH (Riganti et al., 2004)

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