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Spironolactone, pregnenolone 16a-carbonitrile, and other xenobiotics also act by binding PXR, with results similar to cyproterone acetate (Kliewer 2003

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The hormone resistin links obesity to diabetes

Additionally, in vitro findings, such as the observed toxicity of vitamins A and E to cancer cells, may not translate directly into therapeutic benefits in vivo , where complex biological systems can alter the vitamins impact on cancer cells

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Eur J Clin Invest 28:1946, PMID: 9568464 Kurdi M, Sivakumaran V, Duh RJ, Aon MA, Paolocci N, Booz GW (2012) Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes