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HCT116 cells were cultured in McCoys 5A medium (Wisent, Nanjing, China) supplemented with 10% fetal bovine serum (Gibco, Carlsbad, CA), 100 g/ml streptomycin, and 100 units/ml penicillin G in 5% CO 2 at 37C and subcultured by trypsinization when confluent

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PP suppresses somatostatin secretion [29]

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