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Semax is formally an analog of the ACTH(4-10) fragment, the active core Met-Glu-His-Phe capped with a stabilizing Pro-Gly-Pro tail that keeps it from being chewed up too fast, and it is stripped of the parent hormones effects on the adrenal glands, so it acts on the brain without the stress-hormone baggage

People with Lyme disease from New England present differently from those who got Lyme in Pennsylvania or got in Florida or Arkansas, or on the West Coast

Scientific Reports 2015;5:8076, 5 pages

Biochem J 1935;29:1951-69

Abbreviation List ACTH, Adrenocorticotropin hormone ARE, Antioxidant response element ART, Assisted reproductive technology CAT, Catalase CC, Clomiphene citrate COVID-19, Coronavirus disease 2019 CRH, Corticotropin-releasing hormone GnRH, Gonadotropin releasing hormone GPx, Glutathione peroxidase H2O2, Hydrogen peroxide HPA, Hypothalamic-pituitary-adrenal HPG, Hypothalamic-pituitary-gonadal IBS, Irritable bowel syndrome IVF, In vitro fertilization LH, Luteinizing hormone MMP, Mitochondria membrane potential nAChR, Nicotinic acetylcholine receptors NF-B, Nuclear transcription factor-kappa B Nrf2, Nuclear factor erythroid 2-related factor 2 OS, Oxidative stress PCOS, Polycystic ovarian syndrome POI, Premature ovarian insufficiency ROS, Reactive oxygen species SOD, Superoxide dismutase References [1] India Today

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